normInteraction             package:SLGI             R Documentation

_N_o_r_m_a_l_i_z_e _a _m_a_t_r_i_x _o_f _b_i_o_l_o_g_i_c_a_l _i_n_t_e_r_a_c_t_i_o_n_s

_D_e_s_c_r_i_p_t_i_o_n:

     Normalize a square matrix of biological interactions according to
     the number of possible interactions between each biological
     complex.

_U_s_a_g_e:

     normInteraction(data, genename, interactome)

_A_r_g_u_m_e_n_t_s:

    data: Square Matrix of biological complexes that shares one or more
          genes(proteins)

genename: 

interactome: Adjacency matrix where row are genes and columns are
          cellular organizational units. Each entry has value 0 or 1,
          for absence or presence of a gene in a complex, e.g., 'ScISI'

_V_a_l_u_e:

     Square matrix of biological complexes linked by one or more
     interacting proteins and normalized by the possible number of
     interactions between each complex.

_A_u_t_h_o_r(_s):

     N. LeMeur

_S_e_e _A_l_s_o:

     'getInteraction'

_E_x_a_m_p_l_e_s:

     data(Atong)
     data(ScISIC)
     data(SGA)
     SLa2 <- gi2Interactome(Atong, ScISIC)
     ## Search for synthetic lethal interaction
     compM <- getInteraction(SLa2, SGA, ScISIC)
     ## Normalize
     normIntComplex<- normInteraction(compM$bwMat, SGA, ScISIC)

