CAMP              package:GeneticsBase              R Documentation

_G_e_n_o_t_y_p_e _d_a_t_a _f_r_o_m _t_h_e _C_h_i_l_d_h_o_o_d _A_s_t_h_m_a _M_a_n_a_g_e_m_e_n_t _P_r_o_g_r_a_m (_C_A_M_P)

_D_e_s_c_r_i_p_t_i_o_n:

     "This dataset comprises a collection of parent/child trios in the
     Childhood Asthma Management Program (CAMP) Ancillary Genetics
     Study. The CAMP study is a clinical trial of asthmatic children
     (mild to moderate asthma) who were randomized to three different
     asthma treatments (CAMP, 1999). The data set includes 699 complete
     parent/child trios. Some participants are siblings, and there are
     2011 persons from 640 nuclear families in total. Both quantitative
     and qualitative traits are available.

     "Genotypes:

     "The pedigree file, Camp.ped, contains genotype information for
     eight candidate genes (m709, m654, m47, p46, p79, p252, p491,
     p523).  The last seven markers (all but m709) lie in a haplotype
     block.  All the markers are bi-allelic.

     "Phenotypes:

     "The phenotype file, campz.phe, contains 12 quantitative traits
     (zposfevp, zposfvcp, zlogpc20, zampfmea, zpmpfmea, zbdabs, zfevbd,
     zbdpred, zsxcmean, ztoteos, zlogige, zncorpos).  All of the
     phenotypes have been mean centered and standardized.  The fev
     (forced expiatory volume) and fvc (forced vital capacity)
     variables refer to the amount of air that can be expelled from the
     lungs.  The pc20 variable refers to the amount of irritant
     required to cause a 20% drop in fev.  The toteos variable refers
     to total eosinophil (a white blood cell) count, and Ige is a
     measurement of allergen reactivity."

     (quoted from Lange and Kraft 2005)

_U_s_a_g_e:

     data(CAMP)

_F_o_r_m_a_t:

     Object to class 'geneSet'. Covariate information described above.

_S_o_u_r_c_e:

     Lange, C. and Kraft, P. (2005). "Short Course: Genetics
     Associateion Analysis."

_R_e_f_e_r_e_n_c_e_s:

     Lange, C. and Kraft, P. (2005). "Short Course: Genetics
     Associateion Analysis." 

     DeMeo, D. L., C. Lange, et al. (2002). "Univariate and
     multivariate family-based association analysis of the IL-13
     ARG130GLN polymorphism in the Childhood Asthma Management
     Program." Genet Epidemiol 23(4): 335-48.

_E_x_a_m_p_l_e_s:

     library(GeneticsBase)
     data(CAMP)
     head(CAMP) 

