\HeaderA{ALZH}{Sample from National Institute of Mental Health (NIMH) Genetics
Initiative Alzheimer's Disease}{ALZH}
\keyword{datasets}{ALZH}
\begin{Description}\relax
Sample from National Institute of Mental Health (NIMH) Genetics
Initiative Alzheimer's Disease
\end{Description}
\begin{Usage}
\begin{verbatim}data(ALZH)\end{verbatim}
\end{Usage}
\begin{Format}\relax
Object of class 'geneSet'
\end{Format}
\begin{Details}\relax
"This data set is a subsample from the National Institute of Mental
Health (NIMH) Genetics Initiative Alzheimer's Disease (AD) Sample. The
ascertainment and assessment of AD families collected have been
discussed in Blacker et al. (1997). None of the families in this data
set have parental genotype information; practically all of them have
both affected and unaffected offspring. In total there are 901
individuals contained in 301 nuclear families.

"Acknowledgements: We thank Genetics and Aging Research Unit, Rudolph
E. Tanzi, PhD, Director, for providing the data.

"Genotypes

"The pedigree file, Alzh.ped, contains genotype information for two
candidate genes, apoe and a2m.  The apoe gene is multi-allelic, while
the a2m gene is bi-allelic.  The dataset also contains the affection
status (2=affected, 1=unaffected, 0=missing).

"Phenotypes

"We only will be using the Alzheimer dataset to examine affection
status, which is contained in the pedigree file, thus a phenotype file
for these data is not necessary."

(quoted from Lange and Kraft 2005)
\end{Details}
\begin{Source}\relax
Lange, C. and Kraft, P. (2005). "Short Course: Genetics Associateion
Analysis."
\end{Source}
\begin{References}\relax
Lange, C. and Kraft, P. (2005). "Short Course: Genetics Associateion
Analysis."
\end{References}
\begin{Examples}
\begin{ExampleCode}
library(GeneticsBase)
data(ALZH)
head(ALZH)
\end{ExampleCode}
\end{Examples}

