ALZH              package:GeneticsBase              R Documentation

_S_a_m_p_l_e _f_r_o_m _N_a_t_i_o_n_a_l _I_n_s_t_i_t_u_t_e _o_f _M_e_n_t_a_l _H_e_a_l_t_h (_N_I_M_H) _G_e_n_e_t_i_c_s
_I_n_i_t_i_a_t_i_v_e _A_l_z_h_e_i_m_e_r'_s _D_i_s_e_a_s_e

_D_e_s_c_r_i_p_t_i_o_n:

     Sample from National Institute of Mental Health (NIMH) Genetics
     Initiative Alzheimer's Disease

_U_s_a_g_e:

     data(ALZH)

_F_o_r_m_a_t:

     Object of class 'geneSet'

_D_e_t_a_i_l_s:

     "This data set is a subsample from the National Institute of
     Mental Health (NIMH) Genetics Initiative Alzheimer's Disease (AD)
     Sample. The ascertainment and assessment of AD families collected
     have been discussed in Blacker et al. (1997). None of the families
     in this data set have parental genotype information; practically
     all of them have both affected and unaffected offspring. In total
     there are 901 individuals contained in 301 nuclear families.

     "Acknowledgements: We thank Genetics and Aging Research Unit,
     Rudolph E. Tanzi, PhD, Director, for providing the data.

     "Genotypes

     "The pedigree file, Alzh.ped, contains genotype information for
     two candidate genes, apoe and a2m.  The apoe gene is
     multi-allelic, while the a2m gene is bi-allelic.  The dataset also
     contains the affection status (2=affected, 1=unaffected,
     0=missing).

     "Phenotypes

     "We only will be using the Alzheimer dataset to examine affection
     status, which is contained in the pedigree file, thus a phenotype
     file for these data is not necessary."

     (quoted from Lange and Kraft 2005)

_S_o_u_r_c_e:

     Lange, C. and Kraft, P. (2005). "Short Course: Genetics
     Associateion Analysis."

_R_e_f_e_r_e_n_c_e_s:

     Lange, C. and Kraft, P. (2005). "Short Course: Genetics
     Associateion Analysis."

_E_x_a_m_p_l_e_s:

     library(GeneticsBase)
     data(ALZH)
     head(ALZH)

