map_to_func_elem {DominoEffect} | R Documentation |
This function retrieves Uniprot annotations for th efunctional elements in the proteins with significant hotspots and overlaps and maps the hotspot residues to these.
map_to_func_elem(hotspot_results, write_to_file = "NO", ens_release = "75")
hotspot_results |
Object containining information about the hotspot residues identified using the function identify_hotspots(). |
write_to_file |
A character vector defining whether the resulting annotated hotspots should be saved in a file (YES or NO). |
ens_release |
A character vector defining whether the default gene annotations are used, i.e. Ensembl release 75, or if the gene_data correspond to a different Ensembl release. For the current Ensembl version this should be set to: ens_release="www.ensembl.org". For the archive versions to the corresponding archive website. |
Updated results file containing an additional columns with the information on the annotated functional and structural region within which the mutation is mapped.
Marija Buljan <buljan@imsb.biol.ethz.ch> Peter Blattmann <blattmann@imsb.biol.ethz.ch>
data("TestData", package = "DominoEffect") data("DominoData", package = "DominoEffect") data("SnpData", package = "DominoEffect") hotspot_mutations <- identify_hotspots(TestData, DominoData, SnpData) hotspot_mutations <- map_to_func_elem(hotspot_mutations, write_to_file = "NO", ens_release = "75") head(hotspot_mutations)