CorrectBaseLine {synergyfinder}R Documentation

Base line correction

Description

CorrectBaseLine adjusts the base line of drug combination dose-response matrix to make it closer to 0.

Usage

CorrectBaseLine(response.mat, method = c("non", "part", "all"))

Arguments

response.mat

A drug cobination dose-response matrix. It's column name and row name are representing the concerntrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth.

method

A character value to indicate using which method to do baseline correction. Available values ate:

  • non means no baseline corection.

  • part means only adjust the negative values in the matrix.

  • all means adjust all values in the matrix.

Value

A matrix which base line have been adjusted.

Author(s)

Examples

data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response.mat <- data$dose.response.mats[[1]]
adjusted.mat <- CorrectBaseLine(response.mat, method = "part")

[Package synergyfinder version 1.10.6 Index]