HSA {synergyfinder} | R Documentation |
HSA
calculates the synergy score matrix for a block of
drug combination by using Highest Single Agent (HSA) reference model.
HSA(response.mat)
response.mat |
A drug cobination dose-response matrix. It's column name and row name are representing the concerntrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth. |
This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The reference effect of drug combination is the maximal single drug effect".
A matrix for synergy score calculated via Highest Single Agent (HSA).
Liye He liye.he@helsinki.fi
Shuyu Zheng shuyu.zheng@helsinki.fi
Yadav B, Wennerberg K, Aittokallio T, Tang J.(2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.Comput Struct Biotechnol J, 13:504– 513.
Berenbaum MC. (1989). What is synergy? Pharmacol Rev 1990 Sep;41(3):422.
data("mathews_screening_data") data <- ReshapeData(mathews_screening_data) HSA.score <- HSA(data$dose.response.mats[[1]])