Loewe {synergyfinder}R Documentation

Calculate Loewe synergy score

Description

Loewe calculates the synergy score matrix from a dose-response matrix by using a druginteraction reference model introduced by Loewe in 1953.

Usage

Loewe(response.mat, quiet = TRUE, drug.col.model = NULL,
  drug.row.model = NULL)

Arguments

response.mat

A drug cobination dose-response matrix. It's column name and row name are representing the concerntrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth.

quiet

A logical value. If it is TRUE then the warning message will not show during calculation.

drug.col.model

(optional) a character. It indicates the model used for fitting dose-response curve for drug added to columns.

drug.row.model

(optional) a character. It indicates the model type used for fitting dose-response curve for drug added to rows.

Details

Loewe model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The referece effect of drug combination is the expected effect of a drug combined with itself".

The optional arguments drug.col.model, drug.row.model are designed for reuse the single drug dose response model fitting results, if it has been down before. Functions FitDoseResponse and ExtractSingleDrug could be used to calculate these arguments.

Value

A matrix for Synergy score calculated via reference model introduced by Loewe, S.

Author(s)

References

Examples

# No single drug fitted modle before
data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
response.mat <- data$dose.response.mats[[1]]
Loewe.score <- Loewe(response.mat)

# Single drug dose response models have been fitted before.
drug.row.model <- FitDoseResponse(ExtractSingleDrug(response.mat, dim="row"))
drug.col.model <- FitDoseResponse(ExtractSingleDrug(response.mat, dim="col"))
Loewe.score <- Loewe(response.mat, drug.col.model=drug.col.model,
                     drug.row.model=drug.row.model)

[Package synergyfinder version 1.10.3 Index]