FittingSingleDrug {synergyfinder} | R Documentation |
A function to fit single drug dose-response curve with observed response data
FittingSingleDrug(response.mat, fixed = c(NA, NA, NA, NA), nan.handle = c("LL4", "L4"))
response.mat |
a matrix with first column as the drug concentrations and second column as the observed responses |
fixed |
a parameter to specify which parameters are fixed and at what value they are fixed. NAs for parameter that are not fixed. |
nan.handle |
a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs. |
Single drug dose-response curve is fitted with a commonly used 4-paramter log-losistic (4PL) function.
Fitted responses and fitted models are returned.
Liye He liye.he@helsinki.fi
Seber, G. A. F. and Wild, C. J (1989) Nonlinear Regression, New York: Wiley \& Sons (p. 330).
data("mathews_screening_data") data <- ReshapeData(mathews_screening_data) single.drug.fitted <- FittingSingleDrug(data$dose.response.mats[[1]])