BaselineCorrectionSD {synergyfinder} | R Documentation |
A function to do baseline correction on the dose-response matrix for drug combinations with a weighted correction fator
BaselineCorrectionSD(response.mat, Emin = NA, Emax = NA, nan.handle = c("LL4", "L4"))
response.mat |
a dose-response matrix with concentrations as row names and column names. |
Emin |
the minimal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA. |
Emax |
the maximal effect of the drug used in the 4-parameter log-logistic function to fit the dose-response curve. If it is not NA, it is fixed the value assigned by the user. Defaults to NA. |
nan.handle |
a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs. |
A list of the original dose-response matrix without correction and the corrected dose-response matrix.
Liye He liye.he@helsinki.fi, Jing Tang jing.tang@helsinki.fi
data("mathews_screening_data") data <- ReshapeData(mathews_screening_data) data <- BaselineCorrectionSD(data$dose.response.mats[[1]])