estErrProbMethodOfMoments {ppiStats} | R Documentation

## Estimate false positive and false negative error probabilities by method moments.

### Description

Estimate false positive and false negative error probabilities by method moments.

### Usage

    estErrProbMethodOfMoments(nint, nrec, nunr, ntot)

### Arguments

`nint` | Integer vector. True number of interactions. Typically, the function is called for a range of these, returning all possible solutions for that range.
`nrec` | Integer scalar. Observed number of reciprocated edges.
`nunr` | Integer scalar. Observed number of unreciprocated edges.
`ntot` | Integer scalar. Number of proteins which were tested twice (e.g. both as viable bait and as viable prey).

### Details

The model is described in the vignette Stochastic and systematic errors in PPI data, by looking at unreciprocated in- or out-edges by W. Huber, T. Chiang and R. Gentleman.

### Value

Matrix with 5 columns `nint` (a copy of the input argument), `pfp1`, `pfn1`, `pfp2` and `pfn2`, and as many rows as the length of `nint`.

### Author(s)

Wolfgang Huber http://www.ebi.ac.uk/huber

### Examples

    est = estErrProbMethodOfMoments(nint=seq(8000, 40000, by=100), nrec=9722, nunr=15856, ntot=2000)
    if(interactive()) {
      plot(est[, c("pfp2", "pfn2")], type="l", col="blue", lwd=2,
           xlab=expression(p[FP]), ylab=expression(p[FN]))
      abline(h=0, v=0, lty=2)
    }

[Package ppiStats version 1.46.0 Index]