splatEstBCV {splatter} | R Documentation

## Estimate Splat Biological Coefficient of Variation parameters

### Description

Parameters are estimated using the `estimateDisp` function in the `edgeR` package.

### Usage

    splatEstBCV(counts, params)

### Arguments

`counts` | counts matrix to estimate parameters from.
`params` | SplatParams object to store estimated values in.

### Details

The `estimateDisp` function is used to estimate the common dispersion and prior degrees of freedom. See `estimateDisp` for details. When estimating parameters on simulated data we found a broadly linear relationship between the true underlying common dispersion and the `edgR` estimate, therefore we apply a small correction, `disp = 0.1 + 0.25 * edgeR.disp`.

### Value

SplatParams object with estimated values.

[Package splatter version 1.2.2 Index]