diffVar {RnBeads} | R Documentation

## diffVar

### Description

This routine applies the diffVar method from the `missMethyl` package that determines sites exhibiting differential variability between two sample groups

### Usage

    diffVar(meth.matrix, inds.g1, inds.g2, adjustment.table = NULL,
      paired = FALSE)

### Arguments

`meth.matrix` | Matrix containing the methylation information used to calculate differentially variable sites between the two groups
`inds.g1` | Indices in the phenotypic table corresponding to the first group.
`inds.g2` | Indices in the phenotypic table corresponding to the second group.
`adjustment.table` | A `data.frame` containing variables to adjust for in the testing
`paired` | Should the analysis be performed in a paired fashion. If yes, the first index in `inds.g1` must correspond to the first in `inds.g2` and so on.

### Value

P-values as the result of the diffVar method not adjusted for multiple hypothesis testing.

### Author(s)

Michael Scherer

### References

Phipson, Belinda, Oshlack, Alicia (2014) DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging Genome Biology 15(9):465.

[Package RnBeads version 1.10.8 Index]