ImputeIC50 {synergyfinder} | R Documentation

## Impute Missing Value at IC50 Concentration of Drug

### Description

`ImputeIC50` uses the particular experiment's values to predict the missing values at the desired IC50 concentration of the drug. This function is only called when trying to fix a drug at its selected IC50 concentration where the response values have not been tested in experiment.

### Usage

    ImputeIC50(response.mat, col.ic50, row.ic50)

### Arguments

`response.mat` | A matrix. It contains response value of a block of drug combination.
`col.ic50` | A numeric value. The IC50 value of drug added to columns.
`row.ic50` | A numeric value. The IC50 value of drug added to rows.

### Details

`ImputeIC50` fits dose-response models (with `drm` function) by fixing the concentrations of the other drug successively, and uses each fit to predict the missing value at the combination (missing IC50, fixed conc).

### Value

A data frame contains all response value at the IC50 concentration of certein drug. It could be directly passed to function `CalculateRI` for scoring.

### Author(s)

- Shuyu Zheng shuyu.zheng@helsinki.fi

- Jing Tang jing.tang@helsinki.fi

[Package synergyfinder version 3.0.14 Index]