CalculateRI {synergyfinder} | R Documentation

## Calculate Relative Inhibition (RI) for Dose-Response Curve

### Description

Function `CalculateRI` calculates cell line sensitivity to a drug or a combination of drugs from dose response curve.

### Usage

    CalculateRI(df)

### Arguments

`df` | A data frame. It contains two variables: dose the concentrations of drugs. response the response of cell lines at corresponding doses. We use inhibition rate of cell line growth to measure the response.

### Details

This function measures the sensitivity by calculating the Area Under Curve (AUC) according to the dose response curve. The lower border is chosen as lowest non-zero concentration in the dose response data.

### Value

A numeric value. It is the RI score for input dose-response curve.

### Author(s)

- Shuyu Zheng shuyu.zheng@helsinki.fi

- Jing Tang jing.tang@helsinki.fi

### Examples

    # LL.4
    df <- data.frame(dose = c(0, 0.1954, 0.7812, 3.125, 12.5, 50),
                     response = c(2.95, 3.76, 18.13, 28.69, 46.66, 58.82))
    RI <- CalculateRI(df)

[Package synergyfinder version 3.0.14 Index]