.ScoreCurve {synergyfinder} | R Documentation

## CSS Facilitate Function - .ScoreCurve for Curves Fitted by LL.4 Model

### Description

New function used to score sensitivities given either a single-agent or a fixed conc (combination) columns. The function calculates the AUC of the log10-scaled dose-response curve. IMPORTANT: note that with `LL.4` calls, this value is already logged since the input concentrations are logged.

### Usage

    .ScoreCurve(b, c, d, m, c1, c2, t)

### Arguments

`b` | A numeric value, fitted parameter b from `LL.4` model.
`c` | A numeric value, fitted parameter c from `LL.4` model.
`d` | A numeric value, fitted parameter d from `LL.4` model.
`m` | A numeric value, relative IC50 for the curve. log10(e), where e is the fitted parameter e from `LL.4` model.
`c1` | A numeric value, log10(min conc) (this is the minimal nonzero concentration).
`c2` | A numeric value, log10(max conc) (this is the maximal concentration).
`t` | A numeric value, threshold (usually set to zero).

### Value

A numeric value, RI or CSS scores.

### Author(s)

- Shuyu Zheng shuyu.zheng@helsinki.fi

- Jing Tang jing.tang@helsinki.fi

[Package synergyfinder version 3.0.14 Index]