CorrectBaseLine {synergyfinder} | R Documentation

## Base Line Correction for Drug Combination Matrix

### Description

`CorrectBaseLine` adjusts the base line of drug combination dose-response matrix to make it closer to 0.

### Usage

    CorrectBaseLine(response, method = c("non", "part", "all"))

### Arguments

`response` | A drug combination dose-response matrix. It's column name and row name are representing the concentrations of drug added to column and row, respectively. The values in matrix indicate the inhibition rate to cell growth.
`method` | A character value. It indicates the method used for baseline correction. Available values are: non No baseline correction. part Adjust only the negative values in the matrix. all Adjust all values in the matrix.

### Value

A matrix which base line have been adjusted.

### Author(s)

- Shuyu Zheng shuyu.zheng@helsinki.fi

- Jing Tang jing.tang@helsinki.fi

### Examples

    data("mathews_screening_data")
    data <- ReshapeData(mathews_screening_data)
    response <- data$response[data$response$block_id == 1, ]
    adjusted <- CorrectBaseLine(response, method = "part")

[Package synergyfinder version 3.0.14 Index]