HSA {synergyfinder} | R Documentation

## Calculate HSA Synergy Score

### Description

`HSA` calculates the synergy score matrix for a block of drug combination by using Highest Single Agent (HSA) reference model.

### Usage

    HSA(response)

### Arguments

`response` | A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.

### Details

This model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The reference effect of drug combination is the maximal single drug effect".

### Value

A data frame containing the concentrations for drugs, reference effect and synergy score estimated by HSA model.

### Author(s)

- Shuyu Zheng shuyu.zheng@helsinki.fi

- Jing Tang jing.tang@helsinki.fi

### References

- Yadav B, Wennerberg K, Aittokallio T, Tang J.(2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.Comput Struct Biotechnol J, 13:504– 513.

- Berenbaum MC. (1989). What is synergy? Pharmacol Rev 1990 Sep;41(3):422.

### Examples

    data("mathews_screening_data")
    data <- ReshapeData(mathews_screening_data)
    response <- data$response[data$response$block_id == 1,
                              c("conc1", "conc2", "response")]
    HSA.score <- HSA(response)

[Package synergyfinder version 3.0.14 Index]