Loewe {synergyfinder} | R Documentation

## Calculate Loewe Synergy Score

### Description

`Loewe` calculates the synergy score matrix from a dose-response matrix by using a druginteraction reference model introduced by Loewe in 1953.

### Usage

    Loewe(response, Emin = NA, Emax = NA, quiet = TRUE)

### Arguments

`response` | A data frame. It must contain the columns: "conc1", "conc2", ..., for the concentration of the combined drugs and "response" for the observed %inhibition at certain combination.
`Emin` | The expected minimum response value in the 4 parameter log-logistic model.
`Emax` | The expected maximum response value in the 4 parameter log-logistic model.
`quiet` | A logical value. If it is `TRUE` then the warning message will not show during calculation.

### Details

Loewe model is a reference model for evaluating the combination effect of two drugs. The basic assumption of this model is "The referece effect of drug combination is the expected effect of a drug combined with itself".
The optional arguments `drug.col.model`, `drug.row.model` are designed for reuse the single drug dose response model fitting results, if it has been down before. Functions `FitDoseResponse` and `ExtractSingleDrug` could be used to calculate these arguments.

### Value

A data frame containing the concentrations for drugs, reference effect and synergy score estimated by Loewe model.

### Author(s)

- Shuyu Zheng shuyu.zheng@helsinki.fi

- Jing Tang jing.tang@helsinki.fi

### References

- Yadav B, Wennerberg K, Aittokallio T, Tang J.(2015). Searching for Drug Synergy in Complex Dose-Response Landscape Using an Interaction Potency Model.Comput Struct Biotechnol J, 13:504– 513.

- [Loewe, 1953] Loewe, S. (1953). The problem of synergism and antagonism of combined drugs. Arzneimittelforschung, 3(6):285–290.

### Examples

    data("mathews_screening_data")
    data <- ReshapeData(mathews_screening_data)
    response <- data$response[data$response$block_id == 1,
                              c("conc1", "conc2", "response")]
    Loewe.score <- Loewe(response)

[Package synergyfinder version 3.0.14 Index]