enrichMOA {signatureSearch} | R Documentation

## MOA Category Enrichment with Hypergeometric Test

### Description

Given a vector of gene identifiers, this function returns MOA category enrichment results based on a hypergeometric test with duplication support in the test set. The universe for the test is set to the unique genes encoding the target proteins present in the MOA annotation system from the ChEMBL database.

### Usage

    enrichMOA(gene, pvalueCutoff = 0.05, pAdjustMethod = "BH", qvalueCutoff = 0.2)

### Arguments

`gene` | a vector of entrez gene ids (here the test set)
`pvalueCutoff` | pvalue cutoff
`pAdjustMethod` | one of "holm", "hochberg", "hommel", "bonferroni", "BH", "BY", "fdr", "none"
`qvalueCutoff` | qvalue cutoff

### Value

A `feaResult` instance.

### See Also

`feaResult-class`

### Examples

    data(geneList, package="DOSE")
    emoa <- enrichMOA(gene = names(geneList)[seq(3)])
    head(emoa)

[Package signatureSearch version 1.6.3 Index]