circularRandomizeRegions {regioneR} | R Documentation

## Circular Randomize Regions

### Description

Given a set of regions A and a genome, this function returns a new set of regions created by applying a random spin to each chromosome.

### Usage

    circularRandomizeRegions(A, genome="hg19", mask=NULL, max.mask.overlap=NULL, max.retries=10, verbose=TRUE, ...)

### Arguments

`A` | The set of regions to randomize. A region set in any of the accepted formats by `toGRanges` (`GenomicRanges`, `data.frame`, etc...)
`genome` | The reference genome to use. A valid genome object. Either a `GenomicRanges` or `data.frame` containing one region per whole chromosome or a character uniquely identifying a genome in `BSgenome` (e.g. "hg19", "mm10" but not "hg"). Internally it uses `getGenomeAndMask`.
`mask` | The set of regions specifying where a random region can not be (centromeres, repetitive regions, unmappable regions...). A region set in any of the accepted formats by `toGRanges` (`GenomicRanges`,`data.frame`, ...). If `NULL` it will try to derive a mask from the genome (currently only works is the genome is a character string) and if `NA` it will explicitly give an empty mask.
`max.mask.overlap` | numeric value
`max.retries` | numeric value
`verbose` | a boolean.
`...` | further arguments to be passed to or from methods.

### Details

This randomization strategy is useful when the spatial relation between the regions in the RS is important and has to be conserved.

### Value

It returns a `GenomicRanges` object with the regions resulting from the randomization process.

### See Also

`randomizeRegions`, `toDataframe`, `toGRanges`, `getGenome`, `getMask`, `getGenomeAndMask`, `characterToBSGenome`, `maskFromBSGenome`, `resampleRegions`, `createRandomRegions`

### Examples

    A <- data.frame("chr1", c(1, 10, 20, 30), c(12, 13, 28, 40))

    mask <- data.frame("chr1", c(20000000, 100000000), c(22000000, 130000000))

    genome <- data.frame(c("chr1", "chr2"), c(1, 1), c(180000000, 20000000))

    circularRandomizeRegions(A)

    circularRandomizeRegions(A, genome=genome, mask=mask, per.chromosome=TRUE, non.overlapping=TRUE)

[Package regioneR version 1.24.0 Index]