sojournAnno {biomvRCNS} | R Documentation

## Estimate sojourn distribution parameters from posterior information like annotation data

### Description

Using prior information from previous studies or annotation data to determine sojourn distribution parameters

### Usage

    sojournAnno(xAnno, soj.type = "gamma", pbdist = NULL)

### Arguments

`xAnno` | a `GRanges` / `GRangesList` / `TxDb` object, with its first meta column to represent the possible type of the range; Or a `list` object with named initial value vectors matching required parameters for a specific `soj.type`
`soj.type` | type of the sojourn distribution, following types are supported: 'gamma', 'pois', 'nbinom'
`pbdist` | average distance between neighbouring features, in this case in the `link{biomvRhsmm}` call one should only use the rank rather than the position.

### Details

Be default, the hidden-semi Markov model implemented in this package uses a uniform prior for the initial sojourn distribution. However user can provide custom data from related studies to learn the prior of the sojourn distribution. The number of possible state will also be estimated from the unique level of feature type in the first meta column of `xAnno` if it is not a `TxDb` object.

### Value

a list object containing the sojourn distribution parameter

``type`` | type of the sojourn distribution
``fttypes`` | unique levels of the types stored in the first meta column of `xAnno`, alphabetically sorted
``J`` | number of possible states
`\code...` | distribution parameters, 'lambda' and 'shift' for 'pois'; 'size', 'mu' and 'shift' for 'nbinom'; 'scale' and 'shape' for 'gamma'

### Author(s)

Yang Du

### Examples

    	data(encodeTP53)
    	encodeTP53$gmgr # a GRanges object
    	soj<-sojournAnno(encodeTP53$gmgr, soj.type='gamma')

[Package biomvRCNS version 1.32.0 Index]