COVIDsignatures {TBSignatureProfiler} | R Documentation

## A list of published/pre-print COVID-19 signatures.

### Description

A set of 47 COVID-19 gene signatures from various single-cell and bulk RNA-seq publications and preprint manuscripts from early- to mid-2020. This set of signatures uses gene symbols.

### Usage

    COVIDsignatures

### Format

list

### Details

Signature names are composed of the last name of the primary author, followed by the type of sequencing data from which the signature was derived, the tissue from which the signature was derived, and ending with a reference to the cell type, infection status, or disease to which the signature belongs, as defined in the original publication.

Note that in some cases signatures will be positive identifiers of COVID-19 as positive markers of immune cell clusters are often provided for single-cell RNA-seq data; this should be taken into account when creating ROC curves and computing any AUC or disease risk estimates.

### Source

- Wilk_sc_PBMC_monocytes_up: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Wilk_sc_PBMC_monocytes_up: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Wilk_sc_PBMC_monocytes_down: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Wilk_sc_PBMC_NK_cells_up: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Wilk_sc_PBMC_NK_cells_down: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Wilk_sc_PBMCs_ISG_signature: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Wilk_sc_PBMC_activated_granulocytes: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "A single-cell atlas of the peripheral immune response in patients with severe COVID-19." Nature Medicine 26 (7): 1070-1076. https://doi.org/10.1038/s41591-020-0944-y

- Huang_sc_PBMC_IFN_signature: Wilk, A.J., Rustagi, A., Zhao, N.Q. et al. 2020. "Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19." medRxiv.org: https://doi.org/10.1101/2020.03.15.20033472

- Wen_sc_PBMC_monocytes: Wen, W., Su, W., Tang, H. et al. 2020. "Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing." Cell Discovery 6 (31). https://doi.org/10.1038/s41421-020-0168-9

- Wen_sc_PBMC_NK_cells: Wen, W., Su, W., Tang, H. et al. 2020. "Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing." Cell Discovery 6 (31). https://doi.org/10.1038/s41421-020-0168-9

- Wen_sc_PBMC_CD4_T_cells: Wen, W., Su, W., Tang, H. et al. 2020. "Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing." Cell Discovery 6 (31). https://doi.org/10.1038/s41421-020-0168-9

- Wen_sc_PBMC_CD8_T_cells: Wen, W., Su, W., Tang, H. et al. 2020. "Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing." Cell Discovery 6 (31). https://doi.org/10.1038/s41421-020-0168-9

- Wen_sc_PBMC_B_cells: Wen, W., Su, W., Tang, H. et al. 2020. "Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing." Cell Discovery 6 (31). https://doi.org/10.1038/s41421-020-0168-9

- Xiong_bulk_PBMC_gene_signature_up: Xiong Y, Liu Y, Cao L, et al. 2020. "Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients." Emerging Microbes & Infections 9 (1):761-770. https://doi/org/10.1080/22221751.2020.1747363

- Xiong_bulk_PBMC_gene_signature_down: Xiong Y, Liu Y, Cao L, et al. 2020. "Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients." Emerging Microbes & Infections 9 (1):761-770. https://doi/org/10.1080/22221751.2020.1747363

- Xiong_sc_PBMC_cytokines_up: Xiong Y, Liu Y, Cao L, et al. 2020. "Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients." Emerging Microbes & Infections 9 (1):761-770. https://doi/org/10.1080/22221751.2020.1747363

- Xiong_sc_PBMC_cytokines_down: Xiong Y, Liu Y, Cao L, et al. 2020. "Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients." Emerging Microbes & Infections 9 (1):761-770. https://doi/org/10.1080/22221751.2020.1747363

- Liao_sc_BALF_G1_macrophages: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Liao_sc_BALF_G1_2_macrophages: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Liao_sc_BALF_G2_macrophages: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Liao_sc_BALF_G3_macrophages: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Liao_sc_BALF_G4_macrophages: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Liao_sc_BALF_CD8_T_cells_up: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Liao_sc_BALF_CD8_T_cells_down: Liao, M., Liu, Y., Yuan, J. et al. 2020. "Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19." Nature Medicine 26 (6): 842-844. https://doi.org/10.1038/s41591-020-0901-9

- Hadjadj_nanostring_WB_gene_signature_up: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_WB_gene_signature_down: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_WB_ISG_signature: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_WB_mild_moderate_up: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_WB_mild_moderate_down: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_WB_severe_up: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_WB_severe_down: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_critical_up: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Hadjadj_nanostring_critical_down: Hadjadj J, Yatim N, Barnabei L, et al. 2020. "Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients." Science 369 (6504): 718-724. https://doi.org/10.1126/science.abc6027

- Wei_sc_PBMC_inactivated_monocytes: Wei et al. 2020. "Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes during COVID-19 Infection." SSRN: https://dx.doi.org/10.2139/ssrn.3555695

- Wei_sc_PBMC_classical_monocytes: Wei et al. 2020. "Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes during COVID-19 Infection." SSRN: https://dx.doi.org/10.2139/ssrn.3555695

- Wei_sc_PBMCs_T_cells: Wei et al. 2020. "Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes during COVID-19 Infection." SSRN: https://dx.doi.org/10.2139/ssrn.3555695

- Wei_sc_PBMC_B_cells: Wei et al. 2020. "Viral Invasion and Type I Interferon Response Characterize the Immunophenotypes during COVID-19 Infection." SSRN: https://dx.doi.org/10.2139/ssrn.3555695

- Silvin_sc_WB_combined_signature: Silvin A, Chapuis N, Dunsmore G, et al. 2020. "Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19." Cell 182 (6): 1401-1418.E18. https://doi.org/10.1016/j.cell.2020.08.002

- Silvin_sc_WB_monocytes_up: Silvin A, Chapuis N, Dunsmore G, et al. 2020. "Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19." Cell 182 (6): 1401-1418.E18. https://doi.org/10.1016/j.cell.2020.08.002

- Silvin_sc_WB_monocytes_down: Silvin A, Chapuis N, Dunsmore G, et al. 2020. "Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19." Cell 182 (6): 1401-1418.E18. https://doi.org/10.1016/j.cell.2020.08.002

- Silvin_sc_WB_neutrophils_up: Silvin A, Chapuis N, Dunsmore G, et al. "Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19." Cell 182 (6): 1401-1418.E18. https://doi.org/10.1016/j.cell.2020.08.002

- Silvin_sc_WB_neutrophils_down: Silvin A, Chapuis N, Dunsmore G, et al. "Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19." Cell 182 (6): 1401-1418.E18. https://doi.org/10.1016/j.cell.2020.08.002

- Arunachalam_bulk_PBMC_blood_modules: Arunachalam PS, Wimmers F, Mok CKP, et al. 2020. "Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans." Science 369 (6508): 1210-1220. https://doi.org/10.1126/science.abc6261

- Arunachalam_bulk_PBMC_covid_combined: Arunachalam PS, Wimmers F, Mok CKP, et al. 2020. "Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans." Science 369 (6508): 1210-1220. https://doi.org/10.1126/science.abc6261

- Arunachalam_bulk_PBMC_moderate: Arunachalam PS, Wimmers F, Mok CKP, et al. 2020. "Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans." Science 369 (6508): 1210-1220. https://doi.org/10.1126/science.abc6261

- Arunachalam_bulk_PBMC_severe: Arunachalam PS, Wimmers F, Mok CKP, et al. 2020. "Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans." Science 369 (6508): 1210-1220. https://doi.org/10.1126/science.abc6261

- Arunachalam_bulk_PBMC_intensive_care: Arunachalam PS, Wimmers F, Mok CKP, et al. 2020. "Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans." Science 369 (6508): 1210-1220. https://doi.org/10.1126/science.abc6261

- Dunning_bulk_WB_flu: Dunning J, Blankley S, Hoang LT, et al. 2018. "Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza." Nature Immunology 19 (6): 625-635. https://doi.org/10.1038/s41590-018-0111-5

### Examples

    data("COVIDsignatures")

[Package TBSignatureProfiler version 1.4.11 Index]