combineTestPvalsMeth {RnBeads} | R Documentation

## combineTestPvalsMeth

### Description

combine p-values of multiple tests using (a generalization of) Fisher's method. The parameter setting here is taylored to DNA methylation, but can be adapted. Reference: Makambi, K. (2003). Weighted inverse chi-square method for correlated significance tests. Journal of Applied Statistics, 30(2), 225-234.

### Usage

    combineTestPvalsMeth(
      pvalues,
      testWeights = NULL,
      correlated = FALSE,
      methExpectedTestCorrelation = 0.8
    )

### Arguments

`pvalues` | p-values to combine
`testWeights` | weights for the individual tests
`correlated` | are the individual tests correlated
`methExpectedTestCorrelation` | expected correlation. Empirically approximated to the default value of 0.8 for DNA-methylation

### Value

the combined p-value

### Author(s)

Fabian Mueller, Christoph Bock

### Examples

    p.vals <- 10^-c(0,1,5)
    combineTestPvalsMeth(p.vals)

[Package RnBeads version 2.10.0 Index]