create_binaries {CellNOptR} | R Documentation

## Defining the set of binary variables for the ILP implementation of CellNOptR.

### Description

This function takes as input the model and data in a CNOlist object in order to define the set of binary variablese.

### Usage

    create_binaries <- function(model,
                                midas,
                                numberOfExperiments,
                                y_vector)

### Arguments

`model` | the model
`midas` | the midas table
`numberOfExperiments` | the number of experimental conditions
`y_vector` | the variables for each interaction in the PKN

### Author(s)

E Gjerga, H Koch

### References

Alexander Mitsos, Ioannis N. Melas, Paraskeuas Siminelakis, Aikaterini D. Chairakaki, Julio Saez-Rodriguez, and Leonidas G. Alexopoulos. Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data. PLoS Comput Biol. 2009 Dec; 5(12): e1000591.

[Package CellNOptR version 1.38.0 Index]