spqn-package {spqn} | R Documentation

## Spatial quantile normalization

### Description

The spqn package implements spatial quantile normalization (SpQN). This method was developed to remove a mean-correlation relationship in correlation matrices built from gene expression data. It can serve as pre-processing step prior to a co-expression analysis.

### Details

See references for details on spatial quantile normalization.

The main function is `normalize_correlation`. We include a number of plotting functions for examining the mean-correlation relationship, see the vignette for examples.

### References

Y Wang, SC Hicks, KD Hansen (2020). Co-expression analysis is biased by a mean-correlation relationship. bioRxiv 2020.02.13.944777. doi: 10.1101/2020.02.13.944777

[Package spqn version 1.2.0 Index]