Hart {SMAD} | R Documentation

## Hart

### Description

Hart Scoring algorithm based on a hypergeometric distribution error model (Hart et al.,2007).

### Usage

    Hart(datInput)

### Arguments

`datInput` | A dataframe with column names: idRun, idPrey. Each row represent one unique protein captured in one pull-down experiment.

### Value

A dataframe consists of pairwise combindation of preys identified in the input with Hart scores indicating interacting probabilities computed from negative log transformed Hypergeometric test P-values.

### Author(s)

Qingzhou Zhang, zqzneptune@hotmail.com

### References

Hart, G. Traver, Insuk Lee, and Edward M. Marcotte. 'A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality.' BMC bioinformatics 8.1 (2007): 236. https://doi.org/10.1186/1471-2105-8-236

### Examples

    data(TestDatInput)
    datScore <- Hart(TestDatInput)
    head(datScore)

[Package SMAD version 1.6.0 Index]