simes_pval {DAMEfinder} | R Documentation

## Calculate region-level p-value

### Description

This function uses the Simes method to calculate a regional-level p-value based on the single-eBayes p-values. It highly depends on the choice of `maxGap` in `find_dames`.

### Usage

    simes_pval(sat, smtstat, midpt)

### Arguments

`sat` | Output from `get_tstats`.
`smtstat` | (Smoothed) tstat vector from `get_tstats`.
`midpt` | Coordinate vector for each CpG site/tuple.

### Details

When used as a FDR-control method, for positively correlated P-values, Simes method is even closer to the nominal alpha level than the Bonferroni-Holm method.

### Value

Vector of summarized pvals

[Package DAMEfinder version 1.2.0 Index]