qdaCMA {CMA} | R Documentation

## Quadratic Discriminant Analysis

### Description

Performs a quadratic discriminant analysis under the assumption of a multivariate normal distribution in each classes without restriction concerning the covariance matrices. The function `qda` from the package `MASS` is called for computation.

For `S4` method information, see qdaCMA-methods.

### Usage

    qdaCMA(X, y, f, learnind,models=FALSE, ...)

### Arguments

`X` | Gene expression data. Can be one of the following: A `matrix`. Rows correspond to observations, columns to variables. A `data.frame`, when `f` is not missing (s. below). An object of class `ExpressionSet`.
`y` | Class labels. Can be one of the following: A `numeric` vector. A `factor`. A `character` if `X` is an `ExpressionSet` that specifies the phenotype variable. `missing`, if `X` is a `data.frame` and a proper formula `f` is provided. WARNING: The class labels will be re-coded to range from `0` to `K-1`, where `K` is the total number of different classes in the learning set.
`f` | A two-sided formula, if `X` is a `data.frame`. The left part correspond to class labels, the right to variables.
`learnind` | An index vector specifying the observations that belong to the learning set. May be `missing`; in that case, the learning set consists of all observations and predictions are made on the learning set.
`models` | a logical value indicating whether the model object shall be returned
`...` | Further arguments to be passed to `qda` from the package `MASS`

### Value

An object of class `cloutput`.

### Note

Excessive variable selection has usually to performed before `qdaCMA` can be applied in the `p > n` setting. Not reducing the number of variables can result in an error message.

### Author(s)

Martin Slawski ms@cs.uni-sb.de

Anne-Laure Boulesteix boulesteix@ibe.med.uni-muenchen.de

### References

McLachlan, G.J. (1992).

Discriminant Analysis and Statistical Pattern Recognition.

Wiley, New York

### See Also

`compBoostCMA`, `dldaCMA`, `ElasticNetCMA`, `fdaCMA`, `flexdaCMA`, `gbmCMA`, `knnCMA`, `ldaCMA`, `LassoCMA`, `nnetCMA`, `pknnCMA`, `plrCMA`, `pls_ldaCMA`, `pls_lrCMA`, `pls_rfCMA`, `pnnCMA`, `rfCMA`, `scdaCMA`, `shrinkldaCMA`, `svmCMA`

### Examples

    ### load Golub AML/ALL data
    data(golub)
    ### extract class labels
    golubY <- golub[,1]
    ### extract gene expression from first 3 genes
    golubX <- as.matrix(golub[,2:4])
    ### select learningset
    ratio <- 2/3
    set.seed(112)
    learnind <- sample(length(golubY), size=floor(ratio*length(golubY)))
    ### run QDA
    qdaresult <- qdaCMA(X=golubX, y=golubY, learnind=learnind)
    ### show results
    show(qdaresult)
    ftable(qdaresult)
    plot(qdaresult)
    ### multiclass example:
    ### load Khan data
    data(khan)
    ### extract class labels
    khanY <- khan[,1]
    ### extract gene expression from first 4 genes
    khanX <- as.matrix(khan[,2:5])
    ### select learningset
    set.seed(111)
    learnind <- sample(length(khanY), size=floor(ratio*length(khanY)))
    ### run QDA
    qdaresult <- qdaCMA(X=khanX, y=khanY, learnind=learnind)
    ### show results
    show(qdaresult)
    ftable(qdaresult)
    plot(qdaresult)

[Package CMA version 1.48.0 Index]