signeR-package {signeR} | R Documentation

## Empirical Bayesian approach to mutational signature discovery

### Description

The signeR package provides an empirical Bayesian approach to mutational signature discovery. It is designed to analyze single nucleotide variaton (SNV) counts in cancer genomes, but can also be applied to other features as well. Functionalities to characterize signatures or genome samples according to exposure patterns are also provided.

### Details

signeR package focus on the characterization and analysis of mutational processes. Its functionalities can be divided in three steps. Firstly, it provides tools to process VCF files and generate matrices of SNV mutation counts and mutational opportunities, both divided according to a 3bp context (mutation site and its neighboring bases). Secondly, the main part of the package takes those matrices as input and applies a Bayesian approach to estimate the number of underlying signatures and their mutational profiles. Thirdly, the package provides tools to correlate the activities of those signatures with other relevant information, e.g. clinical data, in order to infer conclusions about the analyzed genome samples, which can be useful for clinical applications.

### Author(s)

Rodrigo Drummond, Rafael Rosales, Renan Valieris, Israel Tojal da Silva

Maintainer: Renan Valieris <renan.valieris@accamargo.org.br>

### References

This work has been submitted to Bioinformatics under the title "signeR: An empirical Bayesian approach to mutational signature discovery".

L. B. Alexandrov, S. Nik-Zainal, D. C. Wedge, P. J. Campbell, and M. R. Stratton. Deciphering Signatures of Mutational Processes Operative in Human Cancer. Cell Reports, 3(1):246-259, Jan. 2013. doi:10.1016/j.celrep.2012.12.008.

A. Fischer, C. J. Illingworth, P. J. Campbell, and V. Mustonen. EMu: probabilistic inference of mutational processes and their localization in the cancer genome. Genome biology, 14(4):R39, Apr. 2013. doi:10.1186/gb-2013-14-4-r39.

### Examples

    vignette(package="signeR")

[Package signeR version 1.13.1 Index]