detectionPnegNorm {sesame} | R Documentation

## Detection P-value based on normal fitting the negative controls

### Description

The function takes a `SigSet` as input, computes detection p-value using negative control probes parametrized in a normal distribution and returns a new `SigSet` with an updated pval slot.

### Usage

    detectionPnegNorm(sset, force = FALSE)

### Arguments

`sset` | a `SigSet`
`force` | force rerun even if result already exists

### Details

Background of Grn and Red are estimated separately from negative control probes-parameterized normal distribution. p-value is taken from the minimum of the p-value of the two alleles (color depends on probe design).

### Value

detection p-value

### Examples

    sset <- makeExampleSeSAMeDataSet()
    sset <- detectionPnegNorm(sset)

[Package sesame version 1.5.3 Index]