detectionPnegNormGS {sesame} | R Documentation

## Detection P-value emulating Genome Studio

### Description

The function takes a `SigSet` as input, computes detection p-value using negative control probes parametrized in a normal distribution a la Genome Studio and returns a new `SigSet` with an updated pval slot.

### Usage

    detectionPnegNormGS(sset, force = FALSE)

### Arguments

`sset` | a `SigSet`
`force` | force rerun even if result already exists

### Details

P-value is calculated using negative control probes as the estimate of background where Grn channel and Red channel are merged. But when estimating p-value the Red and Grn are summed (non-ideal).

### Value

detection p-value

### Examples

    sset <- makeExampleSeSAMeDataSet()
    sset <- detectionPnegNormGS(sset)

[Package sesame version 1.5.3 Index]