detectionPnegNormTotal {sesame} | R Documentation

## Detection P-value based on normal fitting the negative controls, channels are first summed

### Description

The function takes a `SigSet` as input, computes detection p-value using negative control probes parametrized in a normal distribution with the two channels summed first and returns a new `SigSet` with an updated pval slot. The SD is summed to emulate the SD of the summed signal (not the most accurate treatment).

### Usage

    detectionPnegNormTotal(sset, force = FALSE)

### Arguments

`sset` | a `SigSet`
`force` | force rerun even if result already exists

### Value

detection p-value

### Examples

    sset <- makeExampleSeSAMeDataSet()
    sset <- detectionPnegNormTotal(sset)

[Package sesame version 1.5.3 Index]