hgParams {ppiStats} | R Documentation

## A wrapper function to build a parameter class for the input of the HyperGTest.

### Description

This function takes a gene set and conducts test for either over or under representation of some category using the Hypergeometric distribution.

The two differences when building the parameter classes are that a conditional test can be performed on the GO dag but not on PFAM categories and an ontology can be assigned to GO but not to PFAM.

### Usage

    ppiBuildParams4GO(geneSet, universe, direction="over", annot="org.Sc.sgd",
                               ontology = "CC", cond=TRUE, pThresh = 0.01)
    ppiBuildParams4PFAM(geneSet, universe, annot ="org.Sc.sgd",
                                  direction = "over", pThresh=0.01)

### Arguments

`geneSet` | A character vector of genes given by the gene locus name.
`universe` | The set of genes by which the geneSet is tested against for over/under representation. The genes are also given by the gene locus names.
`direction` | A character. This parameter can be either set to over or under when testing for GO categories.
`annot` | A character. The annotation package used.
`ontology` | A character: either CC, MF, or BP to describe the GO ontology.
`cond` | A logical. To test within the CO dag, a conditional hypergeometric test can be conducted.
`pThresh` | A numeric. A p-value threshold by which the null hypothesis is rejected.

### Value

A object of class hyperGParams.

### Author(s)

T Chiang

[Package ppiStats version 1.53.1 Index]