moa {mogsa} | R Documentation

## Multiple omics data analysis using MFA or STATIS

### Description

Analysis multiple omics data using MFA or STATIS. The input multiple tables are in a form that columns are samples and rows are variables/features.

### Usage

      moa(data, proc.row="center_ssq1", w.data="inertia", w.row=NULL, statis=FALSE, moa=TRUE)

### Arguments

`data` | A list of `data.frame` or `matrix` that contains the input datas, the columns in all datasets should be samples/observations (which need to be matched) and rows should be variables.
`proc.row` | Preprocessing of rows of datasets, should be one of `none` - no preprocessing, `center` - center only, `center_ssq1` - center and scale (sum of squred values equals 1), `center_ssqN` - center and scale (sum of squred values equals the number of columns), `center_ssqNm1` - center and scale (sum of squred values equals the number of columns - 1) MFA corresponds to "proc.row=center_ssq1" and 'w.data="lambda1"'
`w.data` | The weights of each separate dataset, should be one of `uniform` - no weighting, `lambda1` - weighted by the reverse of the first eigenvalue of each individual dataset or `inertia` - weighted by the reverse of the total inertia. See detail.
`w.row` | If it is not null, it should be a list of positive numerical vectors, the length of which should be the same with the number of rows of each dataset to indicated the weight of rows of datasets.
`statis` | A logical indicates whether STATIS method should be used. See details.
`moa` | Logical; whether the output should be converted to an object of class `moa-class`

### Details

Different methods employs different precessing of row and datasets. For multipple factorial analysis (MFA), the rows of each dataset are first centered and scaled, then each dataset is weighted by the reverse of its first eigenvalue (proc.row=center_ssq1, w.data="lambda1"). This algorithm does not have a well defined criterion to be optimized (see reference).

If statis=TRUE, the statis algorithm will be used, that is, each dataset will be further weighted so that datasets closer to the overall structure will receive a higher weight.

### Value

An object of class `moa-class`.

### Author(s)

Chen Meng

### References

Herve Abdi, Lynne J. Williams, Domininique Valentin and Mohammed Bennani-Dosse. STATIS and DISTATIS: optimum multitable principal component analysis and three way metric multidimensional scaling. WIREs Comput Stat 2012. Volume 4, Issue 2, pages 124-167 Herve Abdi, Lynne J. Williams, Domininique Valentin. Multiple factor analysis: principal component analysis for multitable and multiblock data sets. WIREs Comput Stat 2013

### See Also

`sup.moa`, `mogsa`. More about plot see `moa-class`.

### Examples

      # library(mogsa)
      # loading data
      data(NCI60_4arrays)
      # run analysis
      ana <- moa(NCI60_4arrays, proc.row = "center_ssq1", w.data = "inertia", statis = TRUE)
      # plot
      # plot eigen value
      plot(ana, value = "eig", type = 2)
      # plot the normalized (percentage) eigen value
      plot(ana, value = "tau", type = 2)
      # ploting the observations
      colcode <- as.factor(sapply(strsplit(colnames(NCI60_4arrays$agilent), split="\\."), "[", 1))
      plot(ana, type = 1, value = "obs", col=colcode)
      plot(ana, type = 2, value = "obs", col=colcode, data.pch=1:4)
      # plot variables/features in each data sets
      plot(ana, value = "var", layout=matrix(1:4, 2, 2))
      # plot the RV coefficients for the data sets
      plot(ana, value = "RV")

      # to extract the components representing significant concordance structures between datasets
      bt <- bootMoa(moa = ana, proc.row = "center_ssq1", w.data = "inertia", statis = TRUE, B = 20)

[Package mogsa version 1.21.0 Index]