scHOT_setWeightMatrix {scHOT} | R Documentation

## scHOT_setWeightMatrix

### Description

Create scHOT object from a SingleCellExperiment object

### Usage

    scHOT_setWeightMatrix(
      scHOT,
      weightMatrix = NULL,
      positionType = NULL,
      positionColData = NULL,
      nrow.out = NULL,
      averageAcrossTrajectoryTies = FALSE,
      ...
    )

### Arguments

`scHOT` | A scHOT object
`weightMatrix` | A matrix indicating the weight matrix for scHOT analysis, such as the output from 'trajectoryWeightMatrix' or 'spatialWeightMatrix'. If this is not NULL then other parameters are ignored.
`positionType` | A string indicating the position type, either "trajectory" or "spatial"
`positionColData` | Either trajectory or spatial information for each sample. If positionType is "trajectory" then positionColData should be a character or numeric indicating the subset of colData of the scHOT object. If positionType is "spatial" then positionColData should be a character or numeric vector indicating the subset of colData that give the full spatial coordinates.
`nrow.out` | The number of weightings to include for testing, a smaller value is faster for computation
`averageAcrossTrajectoryTies` | Logical indicating whether ties in the trajectory should be given the same local weights
`...` | parameters for function trajectoryWeightMatrix or spatialWeightMatrix

### Value

A scHOT object with slot weightMatrix saved

### Examples

     data(MOB_subset)
     sce_MOB_subset <- MOB_subset$sce_MOB_subset
     scHOT_spatial <- scHOT_buildFromSCE(sce_MOB_subset,
                                         assayName = "logcounts",
                                        positionType = "spatial",
                                         positionColData = c("x", "y"))
     pairs <- matrix(c("Arrb1", "Mtor", "Dnm1l", "Gucy1b3"), ncol = 2, byrow = TRUE)
     rownames(pairs) <- apply(pairs,1,paste0,collapse = "_")
     scHOT_spatial <- scHOT_addTestingScaffold(scHOT_spatial, pairs)
     scHOT_spatial <- scHOT_setWeightMatrix(scHOT_spatial,
                                           positionColData = c("x","y"),
                                            positionType = "spatial",
                                            nrow.out = NULL,
                                            span = 0.05)

[Package scHOT version 1.0.0 Index]