tnsAREA3,TNS-method {RTNsurvival} | R Documentation

## Compute regulon activity by calling aREA (analytic Rank-based Enrichment Analysis) algorithm

### Description

Uses `tni.area3` function to compute regulon activity for TNS class objects.

### Usage

    ## S4 method for signature 'TNS'
    tnsAREA3(tns, ...)

### Arguments

`tns` | A TNS class, which has been preprocessed
`...` | Additional parameters passed to `tni.area3` function.

### Value

A TNS class, with added regulon activity scores.

### References

Alvarez et al. Functional characterization of somatic mutations in cancer using network-based inference of protein activity. Nature Genetics, 48(8):838-847, 2016.

### See Also

`tni.area3` for additional details.

### Examples

    # load survival data
    data(survival.data)

    # load TNI-object
    data(stni, package = "RTN")

    stns <- tni2tnsPreprocess(stni, survivalData = survival.data,
    keycovar = c('Grade','Age'), time = 1, event = 2)

    stns <- tnsAREA3(stns)

[Package RTNsurvival version 1.12.2 Index]