sim.intervention             package:nem             R Documentation

_S_i_m_u_l_a_t_e _i_n_t_e_r_v_e_n_t_i_o_n_s _i_n _a _N_e_s_t_e_d _E_f_f_e_c_t_s _M_o_d_e_l

_D_e_s_c_r_i_p_t_i_o_n:

     Simulates a knock-down of a list of network nodes and returns the
     network nodes and effect reporters, where effects are expected.

_U_s_a_g_e:

     sim.intervention(x, int)

_A_r_g_u_m_e_n_t_s:

       x: nem object

     int: a character vector of nodes in the network

_V_a_l_u_e:

     list with two slots: 

Sgenes.effected: effected network nodes

Egenes.effected: effected downstream effect reporters

_A_u_t_h_o_r(_s):

     Holger Froehlich

_E_x_a_m_p_l_e_s:

        data("BoutrosRNAi2002")
        D <- BoutrosRNAiDiscrete[,9:16]
        res = nem(D, control=set.default.parameters(unique(colnames(D)), para=c(0.13,0.05))) 
        sim.intervention(res, "rel") # simulate knock-down of rel

