\HeaderA{POSPS}{A Platinum Standard Data Set}{POSPS}
\keyword{datasets}{POSPS}
\begin{Description}\relax
While Yu et al. call this a platinum standard data set, it is
really a gold standard data set for binary physical interactions.
\end{Description}
\begin{Usage}
\begin{verbatim}data(POSPS)\end{verbatim}
\end{Usage}
\begin{Format}\relax
A data frame with 1867 observations on the following 2 variables.
\describe{
\item[\code{ORF1}] a character vector
\item[\code{ORF2}] a character vector
}
\end{Format}
\begin{Details}\relax
These data, reported in the paper below, are intended to represent well
established binary physical interactions between proteins.  This contrasts
with the \emph{gold standard} \code{\LinkA{MIPSGS}{MIPSGS}} which describes 
multi-protein complexes.

Ye et al, describe the construction as follows: \dQuote{
Briefly, the data set contains physical interactions from complex 
protein structures in the Protein Data Bank (Westbrook et al. 
2003), verified interactions from small-scale experiments (Mewes 
et al. 2000; Xenarios et al. 2002; Bader et al. 2003), and protein 
pairs from small MIPS catalog complexes (4 or fewer subunits).}
\end{Details}
\begin{References}\relax
Annotation Transfer Between Genomes:
Protein-Protein Interologs and Protein-DNA Regulogs,
H. Yu et al, Genome Research, 1107-1118, 2004.
\end{References}
\begin{Examples}
\begin{ExampleCode}
data(POSPS)
\end{ExampleCode}
\end{Examples}

