surv_fitness {GSgalgoR} | R Documentation |
Survival fitness function using the Restricted Mean Survival Time (RMST) of each group as proposed by Dehbi & Royston et al. (2017).
surv_fitness(OS, clustclass, period)
OS |
a |
clustclass |
a numeric vector with the group label for each patient |
period |
a number representing the period of time to evaluate in the RMST calculation |
The function computes the Harmonic mean of the differences between Restricted Mean Survival Time (RMST) of consecutive survival curves multiplied by the number of comparisons.
Martin E Guerrero-Gimenez, mguerrero@mendoza-conicet.gob.ar
Dehbi Hakim-Moulay, Royston Patrick, Hackshaw Allan. Life expectancy difference and life expectancy ratio: two measures of treatment effects in randomized trials with non-proportional hazards BMJ 2017; 357 :j2250 https://www.bmj.com/content/357/bmj.j2250
# load example dataset library(breastCancerTRANSBIG) library(Biobase) data(transbig) Train <- transbig rm(transbig) clinical <- pData(Train) OS <- survival::Surv(time = clinical$t.rfs, event = clinical$e.rfs) surv_fitness(OS, clustclass = clinical$grade, period = 3650)