calc_score {DAMEfinder} | R Documentation |
This function calculates the ASM score for every tuple in a given sample. The
ASM score is a multiplication of the log odds ratio by a weight that reflects
the extent of allele-specific methylation. This weight is obtained with the
calc_weight
function.
calc_score(df, beta = 0.5, a = 0.2)
df |
data frame of a sample containing all information per tuple (MM,UU,UM and MU counts, as well as the log odds ratio per tuple) needed for the ASM score. |
beta |
parameter for the |
a |
parameter for the calc_weight function. The weight will be the probability that the MM/(MM+UU) ratio lies between 0.5-a and 0.5+a. |
This function returns an allele-specific methylation (ASM) score for every given tuple in a sample. The ASM score is a product of the log odds ratio and a weight reflecting a measure of allele-specificity using the MM and UU counts.
The same object with an additional column for the ASM score.