org.Hs.egENZYME         package:org.Hs.eg.db         R Documentation

_M_a_p _b_e_t_w_e_e_n _E_n_t_r_e_z _G_e_n_e _I_D_s _a_n_d _E_n_z_y_m_e _C_o_m_m_i_s_s_i_o_n (_E_C) _N_u_m_b_e_r_s

_D_e_s_c_r_i_p_t_i_o_n:

     org.Hs.egENZYME is an R object that provides mappings between
     entrez gene identifiers and EC numbers.

_D_e_t_a_i_l_s:

     Each entrez gene identifier maps to a named vector containing the
     EC number that corresponds to the enzyme produced by that gene.
     The name corresponds to the entrez gene identifier. If this
     information is unknown, the vector will contain an 'NA'.

     Enzyme Commission numbers are assigned by the Nomenclature
     Committee of the International Union of Biochemistry and Molecular
     Biology <URL: http://www.chem.qmw.ac.uk/iubmb/enzyme/> to allow
     enzymes to be identified. 

     An Enzyme Commission number is of the format EC x.y.z.w, where x,
     y, z, and w are numeric numbers. In org.Hs.egENZYME2EG, EC is
     dropped from the Enzyme Commission numbers.

     Enzyme Commission numbers have corresponding names that describe
     the functions of enzymes in such a way that EC x is a more general
     description than EC x.y that in turn is a more general description
     than EC x.y.z. The top level EC numbers and names are listed
     below:

     EC 1 oxidoreductases

     EC 2 transferases

     EC 3 hydrolases

     EC 4 lyases

     EC 5 isomerases

     EC 6 ligases

     The EC name for a given EC number can be viewed at <URL:
     http://www.chem.qmul.ac.uk/iupac/jcbn/index.html#6> 

     Mappings between entrez gene identifiers and enzyme identifiers
     were obtained using files provided by: KEGG GENOME (
     ftp://ftp.genome.jp/pub/kegg/genomes ) on 2008-Apr1

     For the reverse map, each EC number maps to a named vector
     containing the entrez gene identifier that corresponds to the gene
     that produces that enzyme. The name of the vector corresponds to
     the EC number.

_R_e_f_e_r_e_n_c_e_s:

     <URL: ftp://ftp.genome.ad.jp/pub/kegg/pathways>

_E_x_a_m_p_l_e_s:

         x <- org.Hs.egENZYME
         # Get the entrez gene identifiers that are mapped to an EC number 
         mapped_genes <- mappedkeys(x)
         # Convert to a list
         xx <- as.list(x[mapped_genes])
         if(length(xx) > 0) {
           # Get the ENZYME for the first five genes
           xx[1:5]
           # Get the first one
           xx[[1]]
         }
         # For the reverse map:
         # Convert to a list
         xx <- as.list(org.Hs.egENZYME2EG)
         if(length(xx) > 0){
            # Gets the entrez gene identifiers for the first five enzyme
            #commission numbers
            xx[1:5]
            # Get the first one
            xx[[1]]
         }

