unbiasDelta0 {occugene}R Documentation

Unbiased Number of New Knockouts

Description

Unbiased point estimate and confidence intervals for the number of new ORF knockouts in the next d clones.

Usage

unbiasDelta0(d,anno,clone,iter=1000,seed=NULL,alpha=0.05,TR=TRUE)

Arguments

d Number of new clones
anno 2-column matrix of annotation
clone Vector of insertions
iter Number of iterations for the bootstrap
seed Seed for the random number generator
alpha Type I error
TR Report a trace

Details

Fits a parametric function to the cumulative occupancy distribution. Uses a parametric bootstrap to correct for bias and find confidence intervals for the number of new ORF knockouts in the next d clones.

Value

delta0 Unbiased point estimate
CI Confidence interval at the alpha specified

Author(s)

Oliver Will owill4@yahoo.com

References

See the book chapter O. Will (**) in **

See Also

delta0

Examples

data(sampleAnnotation)
data(sampleInsertions)
anno <- cbind(sampleAnnotation$first,sampleAnnotation$last)
clone <- sampleInsertions$position
TR <- TRUE
iter <- 10
seed <- 4
unbiasDelta0(10,anno,clone,iter,seed,TR=TR)

[Package occugene version 1.0.0 Index]