expval {twilight} | R Documentation |
Application of function twilight.pval on leukemia data set of Golub et al. (1999), as given in data(golubMerge)
in library(golubEsets)
.
First step was the variance-stabilizing normalization of Huber et al. (2002) in library(vsn)
: golubNorm <- vsn(exprs(golubMerge))
.
The function call was then expval <- twilight.pval(golubNorm,id)
with id <- as.numeric(golubMerge$ALL.AML)
.
data(expval)
A twilight object.
Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD and Lander ES (1999): Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring, Science 286, 531–537.
Huber W, von Heydebreck A, Sültmann H, Poustka A and Vingron M (2002): Variance stabilization applied to microarray data calibration and to the quantification of differential expression, Bioinformatics 18, suppl. 1, S96–S104.