Tools for Connectivity Map-like analyses


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Documentation for package ‘gCMAP’ version 1.31.2

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A C D E F G I K L M N P R S T U W Z misc

gCMAP-package Tools for Connectivity Map-like analyses

-- A --

annotate_eset_list Function to complile a data frame with per-instance annotation for a list of eSet objects generated by the 'splitPerturbations' function. The output can be used directly as sample.annotation for the 'NChannelSet' function.

-- C --

camera_score Methods for Function 'camera_score' in Package 'gCMAP'
camera_score-method Methods for Function 'camera_score' in Package 'gCMAP'
camera_score-methods Methods for Function 'camera_score' in Package 'gCMAP'
center_eSet A function to to center columns of eSet channels on either their kernel density peak, their mean or their median.
CMAPCollection Class '"CMAPCollection"'
CMAPCollection-class Class '"CMAPCollection"'
CMAPCollection-method Class '"CMAPCollection"'
CMAPResults Class '"CMAPResults"'
CMAPResults-class Class '"CMAPResults"'
cmapTable Class '"CMAPResults"'
cmapTable-method Class '"CMAPResults"'
connectivity_score Broad CMAP gene set enrichment metrics
connectivity_score-method Broad CMAP gene set enrichment metrics

-- D --

docs Class '"CMAPResults"'
docs-method Class '"CMAPResults"'
docs<- Class '"CMAPResults"'
docs<--method Class '"CMAPResults"'
downIds Class '"SignedGeneSet"'
downIds-method Class '"CMAPCollection"'
downIds-method Class '"SignedGeneSet"'

-- E --

effect Class '"CMAPResults"'
effect-method Class '"CMAPResults"'
effect<- Class '"CMAPResults"'
effect<--method Class '"CMAPResults"'
errors Class '"CMAPResults"'
errors-method Class '"CMAPResults"'
errors<- Class '"CMAPResults"'
errors<--method Class '"CMAPResults"'
eSetOnDisk A function to store the assayData of an eSet object as BigMatrix files on disk.
eset_instances A function to subset an eSet with expression data into smaller datasets, each corresponding to a single perturbation experiment.

-- F --

featureScores Methods to obtain scores for CMAPCollection gene sets from a matrix or eSet
featureScores-method Methods to obtain scores for CMAPCollection gene sets from a matrix or eSet
featureScores-methods Methods to obtain scores for CMAPCollection gene sets from a matrix or eSet
fisher_score Hypergeometric probability of gene set enrichment
fisher_score-method Hypergeometric probability of gene set enrichment
fisher_score-methods Hypergeometric probability of gene set enrichment

-- G --

gCMAP Tools for Connectivity Map-like analyses
gCMAPData Example 'NChannelSet'
GeneColorSet-method Methods for 'GeneSet' and 'GeneColorSet'
geneIds-method Class '"CMAPCollection"'
geneIndex Methods for Function 'geneIndex' in Package 'gCMAP'
geneIndex-method Methods for Function 'geneIndex' in Package 'gCMAP'
geneIndex-methods Methods for Function 'geneIndex' in Package 'gCMAP'
generate_gCMAP_NChannelSet Generate a perturbation profile library from expression sets of control/treatment pairs
geneScores Class '"CMAPResults"'
geneScores-method Class '"CMAPResults"'
GeneSet Methods for 'GeneSet' and 'GeneColorSet'
GeneSet-method Methods for 'GeneSet' and 'GeneColorSet'
geneSign Class '"SignedGeneSet"'
geneSign-method Class '"SignedGeneSet"'
geneSign<- Class '"SignedGeneSet"'
geneSign<--method Class '"SignedGeneSet"'
go2cmap Functions to generate species-specific CMAPCollections from Bioconductor KEGG.db, reactome.db or GO.db annotation packages or the wikipathways <URL: http://www.wikipathways.org/index.php/Download_Pathways> project.
gsealm_jg_score Parametric test for testing normally distributed scores for gene set enrichment
gsealm_jg_score-method Parametric test for testing normally distributed scores for gene set enrichment
gsealm_jg_score-methods Parametric test for testing normally distributed scores for gene set enrichment
gsealm_score Methods for Function 'gsealm_score' in Package 'gCMAP'
gsealm_score-method Methods for Function 'gsealm_score' in Package 'gCMAP'
gsealm_score-methods Methods for Function 'gsealm_score' in Package 'gCMAP'

-- I --

incidence-method Class '"CMAPCollection"'
incidence-method Class '"SignedGeneSet"'
induceCMAPCollection Methods for Function 'induceCMAPCollection' in Package 'gCMAP'
induceCMAPCollection-method Methods for Function 'induceCMAPCollection' in Package 'gCMAP'
induceCMAPCollection-methods Methods for Function 'induceCMAPCollection' in Package 'gCMAP'
initialize-method Class '"CMAPCollection"'
initialize-method Class '"CMAPResults"'
initialize-method Class '"SignedGeneSet"'

-- K --

KEGG2cmap Functions to generate species-specific CMAPCollections from Bioconductor KEGG.db, reactome.db or GO.db annotation packages or the wikipathways <URL: http://www.wikipathways.org/index.php/Download_Pathways> project.
ks Broad CMAP gene set enrichment metrics

-- L --

labels Class '"CMAPResults"'
labels-method Class '"CMAPResults"'
labels<- Class '"CMAPResults"'
labels<--method Class '"CMAPResults"'

-- M --

mapIdentifiers-method Class '"SignedGeneSet"'
mapNmerge A function to map eSet featureNames and calculate summaries for many-to-one mapping features
matrix_or_big.matrix-class Class '"matrix_or_big.matrix"'
members Class '"CMAPCollection"'
members-method Class '"CMAPCollection"'
memorize Create a new NChannelSet instance by selecting specific channels and load BigMatrix assayData into memory.
mergeCMAPs This function merged two eSets.
mergeCollections Class '"CMAPCollection"'
mergeCollections-method Class '"CMAPCollection"'
mgsa_score Model-based gene set analysis (MGSA)
mgsa_score-method Model-based gene set analysis (MGSA)
mgsa_score-methods Model-based gene set analysis (MGSA)
minSetSize GeneSetCollection length filtering
minSetSize-method GeneSetCollection length filtering
mroast_score Methods for Function 'mroast_score' in Package 'gCMAP'
mroast_score-method Methods for Function 'mroast_score' in Package 'gCMAP'
mroast_score-methods Methods for Function 'mroast_score' in Package 'gCMAP'

-- N --

nFound Class '"CMAPResults"'
nFound-method Class '"CMAPResults"'
nFound<- Class '"CMAPResults"'
nFound<--method Class '"CMAPResults"'
nSet Class '"CMAPResults"'
nSet-method Class '"CMAPResults"'
nSet<- Class '"CMAPResults"'
nSet<--method Class '"CMAPResults"'

-- P --

padj Class '"CMAPResults"'
padj-method Class '"CMAPResults"'
padj<- Class '"CMAPResults"'
padj<--method Class '"CMAPResults"'
pairwise_compare Generate statistics associated with pairwise differential expression
pairwise_compare_limma Generate statistics associated with pairwise differential expression
pairwise_DESeq Generate statistics associated with pairwise differential expression from RNAseq count data
plot-method Class '"CMAPResults"'
pval Class '"CMAPResults"'
pval-method Class '"CMAPResults"'
pval<- Class '"CMAPResults"'
pval<--method Class '"CMAPResults"'

-- R --

reactome2cmap Functions to generate species-specific CMAPCollections from Bioconductor KEGG.db, reactome.db or GO.db annotation packages or the wikipathways <URL: http://www.wikipathways.org/index.php/Download_Pathways> project.
romer_score Methods for Function 'romer_score' in Package 'gCMAP'
romer_score-method Methods for Function 'romer_score' in Package 'gCMAP'
romer_score-methods Methods for Function 'romer_score' in Package 'gCMAP'

-- S --

S Broad CMAP gene set enrichment metrics
s Broad CMAP gene set enrichment metrics
set Class '"CMAPResults"'
set-method Class '"CMAPResults"'
set<- Class '"CMAPResults"'
set<--method Class '"CMAPResults"'
setSizes Class '"CMAPCollection"'
setSizes-method Class '"CMAPCollection"'
show-method Class '"CMAPResults"'
show-method Class '"SignedGeneSet"'
signed Class '"CMAPCollection"'
signed-method Class '"CMAPCollection"'
signed<- Class '"CMAPCollection"'
signed<--method Class '"CMAPCollection"'
SignedGeneSet Construtor for SignedGeneSet
SignedGeneSet-class Class '"SignedGeneSet"'
SignedGeneSet-method Construtor for SignedGeneSet
signedRankSumTest An implementation of the Wilcox rank sum test / Mann-Whitney test that takes into account the direction / sign of gene set members and possibly the correlation between cases
splitPerturbations Function to split an ExpressionSet downloaded from ArrayExpress based on the experimental factors present in the phenoData slot

-- T --

trend Class '"CMAPResults"'
trend-method Class '"CMAPResults"'
trend<- Class '"CMAPResults"'
trend<--method Class '"CMAPResults"'

-- U --

upIds Class '"SignedGeneSet"'
upIds-method Class '"CMAPCollection"'
upIds-method Class '"SignedGeneSet"'

-- W --

wiki2cmap Functions to generate species-specific CMAPCollections from Bioconductor KEGG.db, reactome.db or GO.db annotation packages or the wikipathways <URL: http://www.wikipathways.org/index.php/Download_Pathways> project.
wilcox_score Methods for Function 'wilcox_score' in Package 'gCMAP'
wilcox_score-method Methods for Function 'wilcox_score' in Package 'gCMAP'
wilcox_score-methods Methods for Function 'wilcox_score' in Package 'gCMAP'

-- Z --

zScores Function to calculate z-scores from p-values
zscores Class '"CMAPResults"'
zscores-method Class '"CMAPResults"'

-- misc --

.DESeq_nbinom Function to perform a DESeq analysis to detect differential expression between perturbation and control groups.